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Rheumatoid Arthritis Helpful Products for Arthritis Pathological Considerations A systemic chronic syndrome characterized by non-specific inflammation of the peripheral joints and related structures. Crippling deformities are the end results. The cause is unknown. Physiological Considerations A hypochromic, normocytic anemia is found in most of these cases with a corresponding very low hemoglobin. A super imposed iron deficiency is also common. The white cell count may be elevated and there is frequently an enlargement of the spleen.