Exclusive Enteric Matrix
Formula Allows for pH Sensitive Release.
Different enzymes are active at different
pH levels. The exclusive enteric matrix formulation of Digestin
allows for two phase, pH sensitive release of the contents
of the capsule, with some of the enzymes being released in
the stomach or gastric phase and others in the upper intestine
or enteric phase.
Incomplete Digestion Can
Cause Food Allergies and Many Diseases.
Proper digestion is a requirement
for optimum health, and incomplete or disordered digestion
can be a major contributor to the development of many diseases.
Not only are foods and nutritional substances of little benefit
when breakdown and assimilation are inadequate, but also,
incompletely digested food molecules can be inappropriately
absorbed into the systemic circulation. This can lead to
various diseases and the development of food allergies.(1)
Enzymatic action originates in four areas: the salivary
glands, the stomach, the pancreas and the wall of the small
intestine. Each enzyme is capable of breaking down only
a specific substance. For example, an enzyme capable of
breaking down fats cannot break down proteins or carbohydrates
or vice versa.(2)
Gastric Phase Releases
Pepsin and HCL
The stomach is primarily responsible
for digestion of proteins and ionization of minerals. The
stomach secretes gastric acid (hydrochloric acid) and various
hormones and enzymes.(1) In Digestin capsules, the gastric
release phase provides the protein digestive enzyme, pepsin;
betaine HCL as a source of hydrochloric acid; and stomach
substance to aid absorption and provide growth and repair
factors for the stomach.
Although much is said about hyperacidity (as often occurs
with peptic ulcer), probably more significant health problems
are caused by lack of gastric acid secretion. There are
many symptoms and signs that suggest impaired gastric acid
secretion, and a number of specific diseases have been
found to be associated with insufficient gastric acid output.
(1,3,4)
Several studies have shown that the ability to secrete
gastric acid decreases with age. Low stomach acidity has
been found in over half of those over age 60.(1,5,6)
Common symptoms of low gastric acidity include:
* Bloating, belching, burning and flatulence immediately
after meals.(1)
* A sense of "fullness" after eating.(1)
* Indigestion, diarrhea or constipation.(1)
* Multiple food allergies.(1)
* Nausea after taking supplements.(1)
* Itching around the rectum.(1)
Other signs of low gastric acidity include weak, peeling
and cracked fingernails, dilated blood vessels in the cheeks
and nose (in non-alcoholics), acne, iron deficiency, chronic
intestinal parasites or abnormal flora, undigested food
in stool, chronic candia infections, upper digestive tract
gassiness.(1)
Enteric Phase Releases
Digestive Enzymes and Bile
The small intestine participates
in all aspects of digestion, absorption and transport of
ingested materials. It secretes a variety of digestive and
protective substances as well as receiving the secretions
of the pancreas, liver and gallbladder.(1)
Diseases involving the small intestine often result in
malabsorption syndromes characterized by multiple nutrient
deficiencies. Common causes of malabsorption include celiac
disease (gluten intolerance), food allergy or intolerance,
intestinal infections and Crohn's disease.(1)
In Digestin, the enteric release phase supplies pancrelipase,
cellulase, duodenal substance and ox bile extract to the
small intestine.
* Pancrelipase, along with bile, functions in the digestion
of fats. Deficiency of lipase results in malabsorption
of fats and the fat soluble vitamins.(1)
* Bile aids in the production of an alkaline reaction in
the intestines and is essential for absorption of fats.(12)
Bile emulsifies the fats, permitting intestinal and pancreatic
lipases to split the triglycerides into diglycerides and
monoglycerides, and finally into free fatty acids and glycerol.(7)
* Bromelain, a protein-digesting enzyme found in pineapple,
is useful as an aid to protein digestion and is effective
as a substitute for pancreatic enzymes in the treatment
of pancreatic insufficiency.(1,8)
* Papain is a protein digesting enzyme isolated from the
unripe papaya fruit. It has been shown to be able to digest
wheat gluten (the protein portion of wheat) and render
it harmless in celiac disease subjects. Taking a papain
supplement with meals may allow some individuals to tolerate
gluten.(1,9,10)
* Cellulase hydrolyzes the plant fiber carbohydrate, cellulose.
Although cellulose cannot be digested by humans, it is
partially digested by the microflora of the intestine.
This natural fermentation process is an important source
of short chain fatty acids. Abnormal intestinal flora is
a common sign of digestive problems related to low gastric
acidity.(1)
The proteolytic (protein-digesting) enzymes and bile also
serve to keep the small intestine free of parasites (including
bacteria, yeast, protozoa and intestinal worms).(1,11)
It is important to remember that digestive problems are
caused by some glandular or organic dysfunction. While
the digestive aid is being used, the glands or organs involved
should also be treated.
In cases of pancreatic insufficiency, supplementation with
pancreatic enzymes is also recommended.(1) Pan 5X and Pan10X
are excellent high potency pancreatic enzyme supplements.
Warning: The product listed in this
publication can not under any circumstances be considered
as treatment, cure, prevention or therapy, or as the only
treatment of therapy for any disease or condition. Nor
can the product under any circumstances be considered as
a substitute or alternative treatment of therapy for any
disease or condition. The product contained in this publication
has not been approved or evaluated by the Federal Drug
Administration. This publication, and the product contained
herein, are not intended to diagnose, treat, cure or prevent
any disease or condition. The product relates to nutritional
support only.
References
1. Murray, Michael and Pizzorno, Joseph, Encyclopedia of
Natural Medicine, Prima Publishing, Rocklin, CA,1991, pp.
43, 50-56.
2. Kirschmann, John and Dunne, Lavon, Nutrition Almanac,
Second Edition, McGraw Hill, New York, 1984.
3. Carper, W.M., Butler, T.J., Kilby, J.O. and Gibson, M.J., "Gallstones,
gastric secretion and flatulent dyspepsia", Lancet,
i, pp. 413-15.
4. Rabinowitch, I.M., "Achlorhydria and its clinical
significance in diabetes mellitus", Am. J. Dig. Dis.,
1949, 18, pp. 322-33.
5. Rafsky, H.A. and Weingarten, M., "A study of the
gastric secretory response in the aged", Gastroent.,
1946, May, pp. 348-52.
6. Davies, D. and James, T.G., "An investigation into
the gastric secretion of a hundred normal persons over the
age of sixty", Brit. Med. J., 1930, i, pp. 1-14.
7. Garrison, R.H. and Somer, E., The Nutrition Desk Reference,
Keats Publishing, New Canaan, CT, 1985, pp. 31-32.
8. Taussig, S., Yokoyama, M., Chinen, Al, et al., "Bromelain,
a proteolytic enzyme and its clinical application. A review",
Hiroshima J. Med. Sci., 1975, 24, pp. 185-93.
9. Messer, M., Anderson, C.M. and Hubbard, L., "Studies
on the mechanism of destruction of the toxic action of wheat
gluten in coeliac disease by crude papain", Gut, 1964,
5, pp. 295-303.
10. Messer, M. and Baume, P., "Oral papain in gluten
intolerance:, Lancet, 1976, ii, p. 1.022.
11. Rubenstein, E., Mark, Z., Haspel, J., et al., "Antibacterial
activity of the pancreatic fluid", Gastrenterol., 1985,
89 pp. 392-7.
12. Dorland, W.A.N., The American Illustrated Medical Dictionary,
Twenty-first edition, W.B. Saunders, Co., Philadelphia, PA,
1947.
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